Mesa of Lost Women (also known as Lost Women) is a 1953 American science fiction film directed by Ron Ormond and Herbert Tevos from a screenplay by the latter and Orville H. Hampton (uncredited).
A couple are found wandering nearly dead in a desert. Recovering, they tell their story. The movie flashes back a year. A mad scientist, Dr. Aranya (Jackie Coogan), has created giant spiders in his Mexican lab in Zarpa Mesa to create a race of superwomen by injecting spiders with human pituitary growth hormones. Women develop miraculous regenerative powers, but men mutate into disfigured dwarves. Spiders grow to human size and intelligence. Aranya invites another scientist, Dr. Masterson, to join him. Masterson visits Zarpa but is horrified…
“Mesa of Lost Women is too damn boring to be an Ed Wood film; it’s more like one by Coleman Francis (Beast of Yucca Flats … ) Instead of the sustained lunacy that we expect from The Master, for every moment of inspired idiocy here – and there are a few, thankfully – there are at least five minutes of uninteresting people wandering aimlessly around the desert, or sitting silently in a cantina. Mesa of Lost Women is bad, all right, but it is not one of The Great Bad Movies.” And You Call Yourself a Scientist!